Forum reviewers thought about the results fascinating and that they contribute to our understanding of the relation of wine to hormonal levels.
On the other hand, they were concerned about methodological issues, including a lack of baseline information and variations in the timing in the coursework of the menstrual period of blood sampling (which could affect estrogen levels). Also, no significant effect of the interventions was seen on blood levels of estradiol. Aromatase inhibitors (AIs) prevent the conversion of androgens to estrogens, and could play a role in the development of breast cancer. This study of 36 pre-menopausal females consisted of a cross-over intervention trial to decide if there were differences between red wine and white wine in their effects on AIs. Subjects sequentially consumed eight ounces of red wine, followed by white wine (or vice versa), each beverage for a one-month period. The investigators concluded that red wine, but not white wine, was associated with significant effects on some indices of estrogen metabolism; free testosterone and luteinizing hormone were increased, but no significant differences were noted in estrogen levels.
Further, the Forum thought that it ought to be pointed out that information are inconsistent on the relation of red wine consumption to the risk of breast cancer; lots of studies do not show beverage-specific effects on risk. More research will be needed to decide if the polyphenols in red wine can play a role in lowering the risk of breast cancer.
